Camotisita intermediate

1. Camoist (59721-16-3) Introduction
Chinese name: 4-(dimethylamino)-2-oxoethyl-2-(4-hydroxyphenyl)acetate
English name: 4-Hydroxybenzeneacetic Acid 2-(Dimethylamino)-2-Oxoethyl Ester
CAS RN:59721-16-3
Constitutional formula :

Formula: C12H15NO4
Molecular weight: 237.10
Melting point: 104-107℃
Appearance: white or white-like powder.
Use: Intermediate in the synthesis of camotisit (a drug for the treatment of pancreatitis).
2. Quality standards
| project | metric | bear fruit | remarks |
| surface | White or white-like powder | White powder | |
| melting point ,℃ | 104.0-107.0 | 105.3-106.2 | |
| fineness ,% | ≥99.0 | 99.85 | LC. Chromatographic column: 25cm*4.5mm 5μm ODS; Mobile phase: methanol-water-HAc (200/800/1, V/V); UV: 235 nm; Sample: 25 mg/10 mL methanol; Injection volume: 5 μL. |
| loss on drying ,% | ≤0.5 | 0.25 | |
| MS(ESI),M+1 | 238.1 | 238.1 | |
| NMR(1H, 13C) | No significant peaks | No significant peaks |