1. Introduction to 2-Amino Pyrazine
Chinese name: 2-Amino pyrazine
English name: Aminopyrazine
the abbreviated form of a name ：AP
CAS RN：5049-61-6
Constitutional formula ：

Formula: C₄H₅N₃
Molecular weight: 95.10
Appearance: white or light yellow crystals
Density: 1.217g/cm³
Melting point: 118–120°C (lit.)
Flash point: 129.08℃
Density: 1.217g/cm
Solubility: soluble in water, soluble in methanol, ethanol and other organic solvents.
Use: synthetic intermediates, fragrances
1. Pharmaceutical synthetic intermediates (primary use)
This is the most important and widely used application of 2-amino pyrazine. Pyrazine ring is a common "advantage structure" in many drug molecules.
Anti-tuberculosis drug: It is a key intermediate in the synthesis of the first-line anti-tuberculosis drug pyrazinamide, which is essential in short-term chemotherapy regimens for tuberculosis treatment.
Anticancer drugs: 2-amino pyrazine serves as the core structural motif for constructing numerous protein kinase inhibitors. For example, it is employed in synthesizing novel targeted anticancer agents for treating renal cell carcinoma, liver cancer, and other malignancies. Its structure enables effective interaction with the ATP-binding site of kinases.
Central nervous system drugs: Pyrazine ring structures are also commonly found in some antidepressants, anti-anxiety drugs and antipsychotics. 2-Amino pyrazine can be easily introduced into these complex molecules as a starting material.
Antihistamines and anti-inflammatory drugs: It is also used to synthesize certain non-sedative antihistamines and other molecules with anti-inflammatory activity.
2. Synthesis of pesticides and herbicides
Nitrogen-containing heterocyclic compounds are also important in the field of agrochemicals.
Fungicides and insecticides: 2-Amino pyrazine can be used as an intermediate in the synthesis of certain fungicides and insecticides. Its structure can be modified to target specific agricultural pathogens or pests.
Herbicides: Some compounds containing pyrazine ring have been developed as selective herbicides, and 2-amino pyrazine is an important precursor for the synthesis of these molecules.
3. Materials science
Pyrazine ring has unique electronic properties, which makes it widely used in the field of functional materials.
Metal-organic frameworks (MOFs) and their coordination polymers: The nitrogen atoms in 2-amino pyrazine serve as excellent coordination atoms, enabling binding with metal ions such as Zn²⁺ and Cu²⁺ to construct metal-organic framework materials. These materials demonstrate significant potential in gas storage (hydrogen and methane), gas separation (CO₂/N₂ separation), and catalysis.
Organic light-emitting diodes (OLEDs): Molecules containing pyrazine rings typically exhibit excellent electron transport properties, making them ideal as primary materials for the electron transport layer or emissive layer in OLED devices. 2-Amino pyrazine serves as an ideal starting point for synthesizing these functional molecules.
4. Dyes and pigments
The pyrazine ring can be part of a chromophore.
Through appropriate chemical modification, 2-aminopyrazine can be used to synthesize some azo dyes or other types of colored compounds, which may be used in textiles, inks or biological dyes.
2. Quality standards